Overview

Our molecular sciences program investigates the chemical properties and behavior of peptides and small molecules with potential applications in longevity research. We focus on understanding how molecular structure influences biological activity, stability, and practical utility as research tools.

This work provides the foundation for all downstream research—ensuring that the compounds we study and provide are well-characterized, stable, and suitable for rigorous investigation.

Capabilities

Solid-phase peptide synthesis (SPPS) for sequences up to 50 amino acids
Non-natural amino acid incorporation and terminal modifications
Cyclic peptide synthesis and disulfide bridge formation
Degradation and stability studies under various conditions
Structure-activity relationship (SAR) studies
Purification by preparative HPLC

Current Research Focus

GH Secretagogues

Characterizing peptides that influence growth hormone release and studying their stability profiles.

GLP-1 Analogs

Investigating incretin mimetics and their structure-activity relationships relevant to metabolic research.

Peptide Stability

Systematic studies of degradation pathways and strategies to improve compound shelf life.

Approach

Every compound synthesized at LLRI undergoes comprehensive characterization before use in downstream studies or release as a research material. We document not just purity and identity, but also solubility behavior, stability under storage conditions, and any observed degradation products.

This thorough approach ensures that our molecular sciences work provides a solid foundation for biochemical and preclinical studies.